WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=8; E=1.33; R=6.00; rawP=6.46e-05; adjP=0.0035
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000006125 NA AP2B1 adaptor-related protein complex 2, beta 1 subunit 163 ENSG00000006125
2  ENSG00000129219 NA PLD2 phospholipase D2 5338 ENSG00000129219
3  ENSG00000120645 NA IQSEC3 IQ motif and Sec7 domain 3 440073 ENSG00000120645
4  ENSG00000009844 NA VTA1 Vps20-associated 1 homolog (S. cerevisiae) 51534 ENSG00000009844
5  ENSG00000181852 NA RNF41 ring finger protein 41 10193 ENSG00000181852
6  ENSG00000148498 NA PARD3 par-3 partitioning defective 3 homolog (C. elegans) 56288 ENSG00000148498
7  ENSG00000102755 NA FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 2321 ENSG00000102755
8  ENSG00000109971 NA HSPA8 heat shock 70kDa protein 8 3312 ENSG00000109971


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=6; E=1.00; R=5.99; rawP=0.0005; adjP=0.0135
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100462 NA PRMT5 protein arginine methyltransferase 5 10419 ENSG00000100462
2  ENSG00000100664 NA EIF5 eukaryotic translation initiation factor 5 1983 ENSG00000100664
3  ENSG00000110321 NA EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 1982 ENSG00000110321
4  ENSG00000110713 NA NUP98 nucleoporin 98kDa 4928 ENSG00000110713
5  ENSG00000023734 NA STRAP serine/threonine kinase receptor associated protein 11171 ENSG00000023734
6  ENSG00000173674 NA EIF1AX eukaryotic translation initiation factor 1A, X-linked 1964 ENSG00000173674


Database:KEGG pathway       Name:Adherens junction       ID:04520
C=73; O=4; E=0.48; R=8.26; rawP=0.0014; adjP=0.0252
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101266 NA CSNK2A1 casein kinase 2, alpha 1 polypeptide 1457 ENSG00000101266
2  ENSG00000171105 NA INSR insulin receptor 3643 ENSG00000171105
3  ENSG00000044115 NA CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1495 ENSG00000044115
4  ENSG00000148498 NA PARD3 par-3 partitioning defective 3 homolog (C. elegans) 56288 ENSG00000148498


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=5; E=1.09; R=4.57; rawP=0.0050; adjP=0.0675
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000080824 NA HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 3320 ENSG00000080824
2  ENSG00000101152 NA DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 80331 ENSG00000101152
3  ENSG00000074695 NA LMAN1 lectin, mannose-binding, 1 3998 ENSG00000074695
4  ENSG00000182446 NA NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 55666 ENSG00000182446
5  ENSG00000109971 NA HSPA8 heat shock 70kDa protein 8 3312 ENSG00000109971


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=4; E=0.90; R=4.47; rawP=0.0127; adjP=0.0762
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134574 NA DDB2 damage-specific DNA binding protein 2, 48kDa 1643 ENSG00000134574
2  ENSG00000009335 NA UBE3C ubiquitin protein ligase E3C 9690 ENSG00000009335
3  ENSG00000182179 NA UBA7 ubiquitin-like modifier activating enzyme 7 7318 ENSG00000182179
4  ENSG00000036257 NA CUL3 cullin 3 8452 ENSG00000036257


Database:KEGG pathway       Name:Tight junction       ID:04530
C=132; O=4; E=0.88; R=4.57; rawP=0.0118; adjP=0.0762
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000221914 NA PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 5520 ENSG00000221914
2  ENSG00000101266 NA CSNK2A1 casein kinase 2, alpha 1 polypeptide 1457 ENSG00000101266
3  ENSG00000044115 NA CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1495 ENSG00000044115
4  ENSG00000148498 NA PARD3 par-3 partitioning defective 3 homolog (C. elegans) 56288 ENSG00000148498


Database:KEGG pathway       Name:p53 signaling pathway       ID:04115
C=68; O=3; E=0.45; R=6.65; rawP=0.0105; adjP=0.0762
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134574 NA DDB2 damage-specific DNA binding protein 2, 48kDa 1643 ENSG00000134574
2  ENSG00000177595 NA PIDD p53-induced death domain protein 55367 ENSG00000177595
3  ENSG00000172667 NA ZMAT3 zinc finger, matrin-type 3 64393 ENSG00000172667


Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=4; E=0.86; R=4.68; rawP=0.0109; adjP=0.0762
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000198753 NA PLXNB3 plexin B3 5365 ENSG00000198753
2  ENSG00000120910 NA PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 5533 ENSG00000120910
3  ENSG00000154134 NA ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 64221 ENSG00000154134
4  ENSG00000180370 NA PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 5062 ENSG00000180370


Database:KEGG pathway       Name:Glycosaminoglycan biosynthesis - chondroitin sulfate       ID:00532
C=22; O=2; E=0.15; R=13.71; rawP=0.0093; adjP=0.0762
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000112309 NA B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) 135152 ENSG00000112309
2  ENSG00000147119 NA CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 56548 ENSG00000147119


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=6; E=2.16; R=2.78; rawP=0.0222; adjP=0.0799
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000080824 NA HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 3320 ENSG00000080824
2  ENSG00000169884 NA WNT10B wingless-type MMTV integration site family, member 10B 7480 ENSG00000169884
3  ENSG00000162434 NA JAK1 Janus kinase 1 3716 ENSG00000162434
4  ENSG00000198793 NA MTOR mechanistic target of rapamycin (serine/threonine kinase) 2475 ENSG00000198793
5  ENSG00000044115 NA CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1495 ENSG00000044115
6  ENSG00000101412 NA E2F1 E2F transcription factor 1 1869 ENSG00000101412




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).